Analyses

In this section:

Efficient analytical solutions to determine posttranslational modifications of asparagine residues in proteins

Deamidation is one of the most frequent posttranslational modifications of biopharmaceuticals and other active substances. This can influence the activity of biological drugs and is therefore important in protein analysis.

The determination of the deamidation rate and identification of the related deamidation position is important.

PANATecs offers tailored solution related deamidation analyses in accordance with international ICH guidelines.

           •     Separation of modified and unmodified protein

                  species by UPL chromatography

           •     Relative quantification of modified and

                  unmodified protein species

           •     Localisation of the deamidation position:

                  endoproteolytic digestion

           •     Batch-to-batch analysis

We have worked for a large number of national and international customers as well as cooperation partners from industry, research and development. They rely on our expertise and extensive equipment, coupled to our ability to implement projects rapidly. We would be glad to provide expert advice on your future projects.

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+49(0)7071 920580