Analyses

In this section:

Efficient analytical solutions to determine posttranslational oxidative modifications of amino acid residues in proteins

The oxidation of amino acid residues has a major influence on hydrophobic interactions and on the stability and biological activity of drugs.
Methionine oxidation is particularly important. Stability studies provide information on the extent of oxidative modification under defined storage conditions (temperature, rel. humidity, light and storage time).

PANATecs offers tailored solutions related to oxidation analyses in accordance with international ICH guidelines:

           •     Design and performance of stability studies

           •     Chromatographic separation of modified and

                 unmodified protein species, including

                 identification by MALDI peptide mass

                 fingerprint or LC-MS analysis

           •     Relative quantification of modified and

                 unmodified protein species

           •     Localisation of oxidised amino acid

                 residues: endoproteolytic digestion,

                 followed by RP-UPLC-QTOF MSE

           •     Batch-to-batch analysis

We have worked for a large number of national and international customers as well as cooperation partners from industry, research and development. They rely on our expertise and extensive equipment, coupled to our ability to implement projects rapidly. We would be glad to provide expert advice on your future projects.

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