Peptide Synthesis

Fischer R, Bachle D, Fotin-Mlezek M, Jung G, Kalbacher H, Brock R.
A targeted protease substrate for a quantitative determination of protease activities in the endolysosomal pathway.
Chembiochem. 2006;7(9):1428-1434.

Baechle D, Cansier A, Fischer R, Brandenburg J, Burster T, Driessen C, Kalbacher H.
Biontiylated fluorescent peptide substrates for the sensitive and specific determination of cathepsin D activity.
Journal of Peptide Science. 2005;11(3):166-174

Baechle D, Fischer R, Cansier A, Brock R, Kalbacher H.
A postcolumn alkalinization procedure enhances the sensitivity of fluorescence detection of fluorescein-labeled substances in RP-HPLC.
Analytical Biochemistry. 2005;345:161-163.

Klatt T, Ouyang Q, Flad T, Koetter I, Buhring HJ, Kalbacher H, Pawelec G, Muller CA.
Expansion of Peripheral CD8+ CD28- T Cells in Response to Epstein-Barr Virus in Patients with Rheumatoid Arthritis.
The Journal of Rheumatology. 2005;32(2):239-51.

Durinovic-Bello I, Schlosser M, Riedl M, Maisel N, Rosinger S, Kalbacher H, Deeg M, Ziegler M, Elliott J, Roep BO, Karges W, Boehm BO.
Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes.
Diabetologia. 2004;47(3):439-450.

Herzog BA, Ott PA, Dittrich MT, Quast S, Karulin AY, Kalbacher H, Karges W, Tary-Lehmann M, Lehmann PV, Boehm BO, Durinovic-Bello I.
Increased in vivo frequency of IA-2 peptide-reactive IFNgamma+/IL-4- T cells in type 1 diabetic subjects.
Journal of Autoimmunity. 2004;23(1):45-54.

Durinovic-Bello I, Maisel N, Schlosser M, Kalbacher H, Deeg M, Eiermann T, Karges W, Boehm BO.
Relationship between T and B cell responses to proinsulin in human type 1 diabetes.
Annals of the New York Academy of Sciences. 2003;1005:288-294.

Schwarz G, Brandenburg J, Reich M, Burster T, Driessen C, Kalbacher H.
Characterization of legumain.
Biological Chemistry. 2002;383(11):1813-1816.

Beck H, Schwarz G, Schroter CJ, Deeg M, Baier D, Stevanovic S, Weber E, Driessen C, Kalbacher H.
Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro.
European Journal of Immunology. 2001;31(12):3726-36.

Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H.
Two new proteases in the MHC class I processing pathway.
Nature Immunology. 2000;1(5):413-418.

Tranquill LR, Cao L, Ling NC, Kalbacher H, Martin RM, Whitaker JN.
Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients.
Multiple Sclerosis. 2000;6(4):220-225.

Virador VM, Santis C, Furumura M, Kalbacher H, Hearing VJ.
Bioactive motifs of agouti signal protein.
Experimental Cell Research. 2000;259(1):54-63.

Antz C, Bauer T, Kalbacher H, Frank R, Covarrubias M, Kalbitzer HR, Ruppersberg JP, Baukrowitz T, Fakler B.
Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate.
Nature Structural Biology. 1999;6(2):146-150.

Lohmann T, Halder T, Engler J, Morgenthaler NG, Khoo-Morgenthaler UY, Schroder S, Seissler J, Scherbaum WA, Kalbacher H.
T cell reactivity to DR*0401- and DQ*0302-binding peptides of the putative autoantigen IA-2 in type 1 diabetes.
Experimental and Clinical Endocrinology & Diabetes. 1999;107(3):166-71.

Schwarzberg H, Kalbacher H, Hoffmann W.
Differential behavioral effects of TFF peptides: injections of synthetic TFF3 into the rat amygdala.
Pharmacology, Biochemistry, and Behavior. 1999;62(1):173-178.

Wissmann R, Baukrowitz T, Kalbacher H, Kalbitzer HR, Ruppersberg JP, Pongs O, Antz C, Fakler B.
NMR structure and functional characteristics of the hydrophilic N terminus of the potassium channel beta-subunit Kvbeta1.1.
The Journal of Biological Chemistry. 1999;274(50):35521-35525.

Wymann D, Bluggel M, Kalbacher H, Blesken T, Akdis CA, Meyer HE, Blaser K.
Human B cells secrete migration inhibition factor (MIF) and present a naturally processed MIF peptide on HLA-DRB1*0405 by a FXXL motif.
Immunology. 1999;96(1):1-9.

Li K, Adibzadeh M, Halder T, Kalbacher H, Heinzel S, Mueller C, Zeuthen J, Pawelec G.
Tumour-specific MHC-class-II-restricted responses after in vitro sensitization to synthetic peptides corresponding to gp100 and Annexin II eluted from melanoma cells.
Cancer Immunology, Immunotherapy. 1998;47(1):32-38.

Curcio-Vonlanthen V, Schneider CH, Frutig K, Blaser K, Kalbacher H.
Molecular parameters in melittin immunogenicity.
Journal of Peptide Science. 1997;3(4):267-76.

Pawelec G, Adibzadeh M, Bornhak S, Friccius H, Halder T, Kalbacher H, Li K, Max H, Mueller C, Sansom D, Thiel F, Zeuthen J.
The role of endogenous peptides in the direct pathway of alloreactivity to human MHC class II molecules expressed on CHO cells.
Immunological Reviews. 1996;154:155-173.

Pawelec G, Max H, Halder T, Bruserud O, Merl A, da Silva P, Kalbacher H.
BCR/ABL leukemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donors.
Blood. 1996;88(6):2118-2124.

Antimicrobial Peptides

Baechle D, Flad T, Cansier A, Steffen H, Schittek B, Tolson J, Herrmann T, Dihazi H, Beck A, Mueller GA, Mueller M, Stevanovic S, Garbe C, Mueller CA, Kalbacher H.
Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of DCD-1L.
The Journal of Biological Chemistry. 2006;281(9):5406-5415.

Rieg S, Garbe C, Sauer B, Kalbacher H, Schittek B.
Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions.
The British Journal of Dermatology. 2004;151(3):534-539.

Weidenmaier C, Kokai-Kun JF, Kristian SA, Chanturiya T, Kalbacher H, Gross M, Nicholson G, Neumeister B, Mond JJ, Peschel A.
Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections.
Nature Medicine. 2004;10(3):243-245.

Flad T, Bogumil R, Tolson J, Schittek B, Garbe C, Deeg M, Mueller CA, Kalbacher H.
Detection of dermcidin-derived peptides in sweat by ProteinChip technology.
Journal of Immunological Methods. 2002;270(1):53-62.

Muller CA, Markovic-Lipkovski J, Klatt T, Gamper J, Schwarz G, Beck H, Deeg M, Kalbacher H, Widmann S, Wessels JT, Becker V, Muller GA, Flad T.
Human alpha-defensins HNPs-1, -2, and -3 in renal cell carcinoma: influences on tumor cell proliferation.
The American Journal of Pathology. 2002;160(4):1311-1324.

Peschel A, Jack RW, Otto M, Collins LV, Staubitz P, Nicholson G, Kalbacher H, Nieuwenhuizen WF, Jung G, Tarkowski A, van Kessel KP, van Strijp JA.
Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine.
The Journal of Experimental Medicine. 2001;193(9):1067-1076.

Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S, Schirle M, Schroeder K, Blin N, Meier F, Rassner G, Garbe C.
Dermcidin: a novel human antibiotic peptide secreted by sweat glands.
Nature Immunology. 2001;2(12):1133-1137.

Halder TM, Bluggel M, Heinzel S, Pawelec G, Meyer HE, Kalbacher H.
Defensins are dominant HLA-DR-associated self-peptides from CD34(-) peripheral blood mononuclear cells of different tumor patients (plasmacytoma, chronic myeloid leukemia).
Blood. 2000;95(9):2890-2896.

Peschel A, Otto M, Jack RW, Kalbacher H, Jung G, Gotz F.
Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides.
The Journal of Biological Chemistry. 1999;274(13):8405-8410.

Polyclonal Antibodies

Lautwein A, Kraus M, Reich M, Burster T, Brandenburg J, Overkleeft HS, Schwarz G, Kammer W, Weber E, Kalbacher H, Nordheim A, Driessen C.
Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner.
Journal of Leukocyte Biology. 2004;75(5):844-855.

Leichtle A, Rauch U, Albinus M, Benohr P, Kalbacher H, Mack AF, Veh RW, Quast U, Russ U.
Electrophysiological and molecular characterization of the inward rectifier in juxtaglomerular cells from rat kidney.
The Journal of Physiology. 2004;560(2):365-376.

Moeschel K, Beck A, Weigert C, Lammers R, Kalbacher H, Voelter W, Schleicher ED, Haring HU, Lehmann R.
Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1.
The Journal of Biological Chemistry. 2004;279(24):25157-25163.

Pesch UE, Fries JE, Bette S, Kalbacher H, Wissinger B, Alexander C, Kohler K.
OPA1, the disease gene for autosomal dominant optic atrophy, is specifically expressed in ganglion cells and intrinsic neurons of the retina.
Investigative Ophthalmology & Visual Science. 2004;45(11):4217-4225.

Rieg S, Garbe C, Sauer B, Kalbacher H, Schittek B.
Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions.
The British Journal of Dermatology. 2004;151(3):534-539.

Liebner S, Kniesel U, Kalbacher H, Wolburg H.
Correlation of tight junction morphology with the expression of tight junction proteins in blood-brain barrier endothelial cells.
European Journal of Cell Biology. 2000;79(10):707-717.

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